Recently, researchers have been working on examining the biosafety and neurobehavioral effects of 33.0 Tesla high static magnetic fields (SMF). They used the Constant High Magnetic Field Installations (SHMFF) self-built biological research platform in a series of studies. The experiments were conducted by Prof. Dr. Hefei Institutes of Physical Sciences of the Chinese Academy of Sciences. Performed by Xin Zhang's group.
They published the first reports on the biosafety of 30 Tesla SMF and the neurobehavioral effects of 20 Tesla and 30 Tesla SMF on healthy mice in the Magnetic Resonance Imaging and European Journal of Radiology.
Ultra-high-field magnetic resonance imaging (MRI) has grown rapidly in recent years, largely due to its high imaging resolution. Clinically validated 7 Tesla MRI and 21.1 Tesla MRI have been used effectively on rodents. However, research on the biosafety of high magnetic fields is still lacking by over 20 Tesla and there is a research gap of over 30 Tesla.
Magnetic field intensity and exposure time were increased by Xin Zhang's group based on the results of a previous biosafety study using 3.5-23.0 Tesla SMF. Healthy C57BL/6J mice were subjected to 7.0-33.0 Tesla SMF for one hour.
For two months after exposure, all mice were fed regularly. Most mice were still within the normal reference range, except for a few indicators of metabolic, hepatic, and hepatocellular function that were adversely affected by the magnetic field.
Within two months of exposure, behavioral tests revealed that high SMF reduced anxiety and improved social and spatial memory in mice.
The better neurocognitive effects demonstrated in behavioral experiments of healthy mice exposed to a 3.5-23.0 Tesla magnetic field for two hours could be attributed to the higher expression of calcium/calmodulin-dependent protein kinase II in the mouse hippocampus.
Further research by Zhang's team revealed that 7 Tesla SMF could successfully treat depressive mouse symptoms.
These findings may also suggest that high SMF has the potential to be used as an antidepressant in the future. They also provide useful safety data for the development of ultrahigh MRI.
Günceleme: 01/08/2022 18:40