Sabancı University faculty member Bahattin Koç and his team produced an aorta with a XNUMXD bioprinter using living cells.
The study, which is the first in the world, will be one of the steps in artificial organ production.
The aorta was produced at the SABANCI University Nanotechnology Application and Research Center using the world's first 3D bioprinter and human living cells. University's Faculty of Engineering and Natural Sciences Production Systems Program faculty member Assoc. Dr. Bahattin Koç and his team are also working on producing bifurcated veins. Explaining the 300 thousand lira project supported by TÜBİTAK, Assoc. Dr. Koç listed the reasons for starting with the aorta as follows: “Since the aorta is the largest and only vessel in the body, it is not possible to treat it with a vein to be taken from another part of the body. Synthetic veins are used in the treatment, but they are not like one's own veins. The second reason is that if we are going to produce tissues and organs with a 3D printer, vascular tissue must be created to nourish these tissues and organs. With our study, the abdominal aortic vessel will be able to be produced using the patient's own cells or stem cells, and the artificial vessel will be transplanted to the patients. The pharmaceutical industry can conduct its trials on tissues produced in this way.”
EINSTEIN'S CAUSE OF DEATH
Explaining that the cause of death of scientist Einstein was an abdominal aortic aneurysm, Koç said, "As a result of our study, the abdominal aortic vessel can be produced using the patient's own cells or stem cells, and the artificial vessel will be transplanted to such patients." Stating that they use living cells as bio-ink in 3D printing, and that the bio-ink is obtained by duplicating purchased fibroblasts (main cells of connective tissue), Koç continued: “The most important goal of the project is to produce the patient's own normal cells and stem cells with a 3D bio-printer. to produce an exact copy of a tissue or even an organ. This will eliminate the problems of rejection by the body. It is much more difficult to produce soft tissues with a 3D printer. But we are thinking of working in soft tissue.”
2 production in 1 hours
An aorta can be obtained in 3-1.5 hours with a 2D printer. Here is the process:
The data is extracted by MR scanning of the aortic tissue sample.
With the developed algorithms, the printing path of the cells is calculated according to the anatomy of the tissue to be produced.
Support structures for cells are determined. The difference of this study is that the cells support each other and are determined in accordance with the 3D anatomy of the tissue.
Commands to control the bio-printer are saved to the file.
Using these commands, it is controlled where the bio-printer will print cells and where support structure will be printed.
The printer 3D prints large vascular tissue, similar to the aorta, suitable for its anatomical structure, using living cells and biomaterials.
source : hurriyet